I have had trouble with Apple Wireless Mouse not being recognized after waking on both my PB12 and iMacG5-20. Two things to do or check: - Wireless mouse firmware update done. - use fresh batteries. I was using rechargeable NmHI batts and after a few months they started giving me the dead-upon-wake behavior. I slapped in fresh alkaline disposable batts and the mouse haas been fine. I suspect that the voltage in the modestly tired NmHI batts was not up to snuff.