After some experimentation, I have found the following settings convenient/useful for (Apple) Mail: [Rotate Right] to [Scroll Down] when reading a message; [Rotate Left] to [Scroll Up] when reading a message; [Click] to [Send Key] -> [Delete] to delete a message: [Long Click] to [Send Key] -> [Down Arrow] to move to the next message (without deleting the current one); [Click & Rotate Right} to [Send Key] -> [Right Arrow] to expand a thread; and [Click & Rotate Left] to [Send Key] -> [Left Arrow] to collapse a thread. These allow me to go through a Mailbox quickly and with minimal keyboard/mouse usage. Can anyone suggest customized settings to program for other applications? Thanks!