I know that this sounds like a completely bizarre suggestion, but have you tried disconnecting any connected USB or Firewire cables from your computer? I had similar unexplained lockups and slowdowns during file transfers, and if memory serves, found some bizarre combination of USB hubs/peripherals was causing the problem. I can get a complete freeze of the UI on my system; can't force-quit, invoke terminal, etc. But I can simply yank the USB cable out of my iMac (thereby disconnecting a couple of hubs, multiple external drives, scanner, etc...yes I know not advisable) and suddenly my system will spring back to life. Let me know if that helps. Michael