I made the switch to Intel first with an iMac in February, and then with a Macbook in November, after having the PPC versions. It's difficult to say if you will have trouble without specifying which peripherals you use (if there are drivers available or not, etc.). I had no problem whatsoever with my Brother printers and scanners, even before "universal" drivers came out. On the application side, I have had zero difficulty using any applications on my Intel Macs. The only consideration is if you use Classic/OS 9 or not. In that case, then you won't be able to run those apps. Michael